TSC2 and atrial fibrillation: In addition, the number of all TSC2 somatic mutations per sample analyzed and the number of TSC2 CC:GG>TT:AA mutations per sample analyzed were higher in TSC-FAF than in TSC-NS samples (n = 10), and higher in TSC-NS than in TSC-UF/TSC-nipple AF (n = 4) and TSC-blood/semen samples (n = 14) (P = 0.0002 and P < 0.0001, Kruskal-Wallis test; Figure 5A).