The distribution of the nonsynonymous/intronic somatic TP53 mutations in FAFs mirrors the distribution of somatic mutations reported previously in normal keratinocytes/skin cancers (15–17, 27–39) (r = 0.92, P < 0.0001; Supplemental Figure 5B and Supplemental Table 1.2), including multiple mutations at well-known hotspots (e.g., aa 248) (Figure 6). The gene discussed is TP53; the disease is skin neoplasm.