ACVR2B and obesity due to melanocortin 4 receptor deficiency: Another study has shown that miRNAs in exosomes (a subpopulation of EVs) from obese visceral adipocytes could down-regulate the expression of ACVR2B in the TGF-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}}{}$\beta$\end{document} signaling pathway (27), which plays a crucial role in obesity and insulin resistance (28–30).