MC1R and melanoma: Stepwise conditional logistic regression was then deployed to identify three independent haplotypes in this region, with the lead SNPs for these three independent signals corresponding to the known MC1R melanoma-predisposing alleles p.Arg151Cys (rs1805007), p.Arg160Trp (rs1805008) and p.Asp294His (rs1805009) (Fig. 2A).