Its basic indications include symptoms caused by Yang deficiency in the kidney system, such as weakness in the lower extremities, chills, frequent urination, back pain, diarrhea, cold in the extremities, tinnitus, lethargy, edema, renal colic, erectile dysfunction, and decreased sexual desire.[7] A previous study found that GSH decreased serum leptin levels and insulin resistance index as well as increased insulin sensitivity in rats. This evidence concerns the gene LEP and erectile dysfunction.