TCN1 and Diamond-Blackfan anemia: Moreover, it is well established that mutations in around 20 different RPGs, mostly leading to haploinsufficiency of individual r-proteins, result in the development of a ribosomopathy called Diamond-Blackfan anemia (DBA) (Narla and Ebert, 2010; Danilova and Gazda, 2015; Da Costa et al., 2018; Aspesi and Ellis, 2019), whose defining characteristics include reduced proliferation and increased apoptosis of erythroid progenitor cells, raising the possibility that proteotoxic stress could contribute to the manifestation of DBA (Recasens-Alvarez et al., 2021).