TCN1 and neurodegenerative disease: Taking into account the findings of our study and the above considerations, perturbed proteostasis, elicited by unassembled r-proteins such as RPL3 and RPL4, could not only contribute to the development of DBA but possibly also influence the aging process and be of relevance to the etiology of diverse developmental disorders and even neurodegenerative diseases of protein aggregation (Kaushik and Cuervo, 2015; Szybińska and Leśniak, 2017; Maor-Nof et al., 2021).