HUWE1 and neurodevelopmental disorder: In this respect, it is worth mentioning that genetic changes in HUWE1, encoding the ortholog of Tom1, are associated with multiple neurodevelopmental disorders, prominently including X-linked intellectual disability (Giles and Grill, 2020), and that reduced HUWE1 levels, due to a disease-causing mutation, increase p53 signaling (Aprigliano et al., 2021).