Engagement of human endothelial receptors by infected red blood cells is also known to trigger local signalling processes through angiogenic factors angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) both of which contribute to or are important drivers of CM pathogenesis (Yeo et al., 2008). This evidence concerns the gene ANGPT2 and cutaneous mastocytosis.