Therefore, to examine whether some GPCRs and TRP channels are involved in B. pertussis-induced cough, we applied various antagonists for GPCRs (Bdk B1 and B2 receptors, neurokinin 1 to 3 receptors, and prostaglandin E2 receptor EP3) and TRP channels (TRPV1, TRPV4, and TRPA1) in our mouse model. This evidence concerns the gene TRPV1 and Cough.