LDHA and cancer: However, ALDH is the most commonly used marker for CSCs, because in various types of cancers, ALDHhigh cells display many characteristics of stem cells, such as self-renewal, clonogenicity, tumor-initiating capacity, and drug resistance.65 A second limitation may be related to the observed recurrence rates, which were higher than those reported by other authors, although this issue can be reasonably explained by our moderate sample size.