TNF and ankylosing spondylitis: For instance, etanercept is known to inhibit TNF-alpha-induced pro-inflammatory activity in rheumatoid arthritis[48] patients and reduce the severity of psoriasis.[49] Adalimumab is a novel TNF-alpha antibody that can slow the progression of rheumatoid arthritis[50] and alleviate the severity of ankylosing spondylitis.