TNF and Familial prostate cancer: Some proinflammatory cytokines have been confirmed in the development of MS, such as IL-1, IL-6, IL-12, and TNF.[66] Toll-like receptors recognized and presented antigens to initiate an inflammatory response.[67] The results suggest that the hsa05215: Prostate cancer and hsa05152: Tuberculosis play core roles in the network and indicate that the pathways are extremely important in the pathogenesis of MS.