TNF and relapsing-remitting multiple sclerosis: For instance, the expression of AKT-1 and phosphorylated-Akt1 (p-Akt1) decreased in CD4+ T cell and regulatory T (Treg) cells of RRMS.[37] Numerous studies have found IL-4 and IL-4R to be associated with MS.[38] Increased TNF levels were previously the meninges and CSF in MS.[39] Moreover, miR-155-5p is known to regulate the pathological process of MS by targeting the aforementioned genes.