YM extract administration to diabetic rats showed an anti-diabetic effect through inhibition of a-amylase and a-glucosidase activity.[5] Additionally, YM administration to rats with T2DM exerted protective effects on beta cells by suppressing NF-κB expression in pancreatic islets.[6] Additionally, YM administration was found to improve T2DM-related insulin resistance by increasing IRS-2 expression in the insulin signaling pathway or regulating the PI3K/Akt signaling path-way.[7,8]. The gene discussed is IRS2; the disease is type 2 diabetes mellitus.