HLA-C and autoimmune disease: The previous 2 latest research results also support our conclusion.[16,17] The risk of autoimmune diseases in TS patients is around twice that of the general female population, and the spectrum covers IBD and celiac disease.[18] This autoimmune disease may be correlated with an MHC locus on the long arm of the X chromosome, and the deletion of this region may cause insufficient immune regulation.[19]