RNA molecular analysis was conducted on peripheral blood cells from patients with stable coronary artery disease; the mRNA levels of inflammation and oxidative stress markers, such as RORγt (T helper cell 17 cell marker), FoxP3 (regulatory T cell marker), NLRP3, ICAM1, SIRT1, Notch ligands JAG1 and DLL4, and HES1 (Notch target gene), were determined; the changes in SIRT1 and HES1 mRNA were related to serum epidermal growth factor.[8] The EGF level was down-regulated in the key differential genes selected by us. This evidence concerns the gene HES1 and coronary artery disorder.