Various factors showed to have prognostic significance included age, tumor size, rupture of tumor, postoperative residual tumor, nonstaging surgery, mitotic activity, nuclear atypia, aneuploidy, p53 over-expression, high Ki-67, and stage of the disease.[14,26-30] Only stage of the disease had been consistently shown in various studies to affect survival. This evidence concerns the gene MKI67 and neoplasm.