In addition, since the endothelium actively expresses ACE2 and has been shown to be an active site of SARS-CoV-1 infection, it is possible that SARS-CoV-2 can directly infect these cells.[50] However, the difference in the infection of the different micro and macrovascular beds and between the organs is justified, since, as the entry of the virus into the cells occurs mainly through endocytosis,[51,52] it will strongly depend on the expression in each ACE2 tissue and the availability of transmembrane protease serine 2 protein or other proteases to cleave the viral peak.[53]. This evidence concerns the gene TMPRSS2 and infection.