This may illustrate the lack of TP53 mutations in L-FLAC cases indicating that the good prognosis of this tumor may be related to fewer molecular alterations.[21] However, in this case, TP53 was mutated (exon8: c.868C>T: p. R290C), and its mutation abundance was 1.8%, which is different from the reported related cases, and more cases need to be accumulated and studied on the role of TP53 mutation in the development of L-FLAC. This evidence concerns the gene TP53 and neoplasm.