TP53 and lung carcinoma: Mutations in TP53 also differ greatly in L-FLAC and H-FLAC, which show nuclear p53 overexpression, but p53 expression is found in L-FLAC.[6,8] Bodner and Koss found through a large case collection that no TP53 mutation was contained in L-FLAC cases, that mutations in TP53 were present in H-FLAC, and that their mutation frequency was similar to that of conventional lung cancer.