CQ and HCQ are drugs associated with multiple intracellular processes, especially with antimalarial, anti-inflammatory, and immune responses.[33] The specificity of CQ against malaria consists of an active mechanism of accumulating acidic vesicles, lysosomes, and Golgi complex leading to enzyme dysfunction (depending on the gradient of hydrogen ions in the medium.[34,35] In patients with lupus, CQ acts on pro-inflammatory cytokines—reducing interleukin 6, 18, and tumor necrosis factor alpha.[36]. This evidence concerns the gene TNF and malaria.