Activation of the STAT3‐dependent pathways including the STAT3/FAK/ERK pathway, STAT3/Oct‐4 pathway in various cancer cells, and the IL‐8/STAT3 pathway and EGFR/STAT3/Sox‐2 pathways in TAMs are shown to contribute to the cancer stemness.179, 180, 181, 182. The gene discussed is POU5F1; the disease is cancer.