And STAT3 expression is 10.6‐fold higher in head and neck squamous cell carcinoma (HNSCC) tissues, compared to normal mucosa tissues derived from non‐HNSCC patients, leading to that activated STAT3 is regarded as an oncogene.38, 39, 40, 41, 42. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.