KLK3 and posterior cortical atrophy: External validation on several large cohorts showed an AUC of 0.76.17 The PLUM RC includes age, PSA, DRE, prostate volume, ancestry, family history of PCa, prior negative biopsy, and MRI results, which resulted in an AUC of 0.88 for biopsy naïve and 0.87 for prior negative biopsy men.