KLK3 and posterior cortical atrophy: RCs are based on data of large cohorts and use a combination of patient-specific characteristics (e.g. age, digital rectal examination (DRE), prostate volume, prostate-specific antigen (PSA) levels, previous prostate biopsy results, prostate MRI results) to estimate the risk of having PCa at biopsy.7 RCs show significantly better predictive accuracy compared with individual variables, such as PSA alone.