Although no study so far illustrated the effect of antipsychotics on IL-15Rα, several data showed the significant changes in circulating IL-15 levels in schizophrenia patients than that in controls, yet no significant change of IL-15 levels were found in patients prior and pose-treated with 6-8 weeks of antipsychotics (29, 57). The gene discussed is IL15RA; the disease is schizophrenia.