CXCL8 and COVID-19: Table 4 showed the results of validation study for the suggestive causal association cytokines (IL5 in cytokines to COVID-19 direction, and bNGF, IL8 in COVID-19 to cytokines direction) discovered in R5A2 data set. In the cytokines to COVID-19 direction, IL5 also showed marginal association (P = 0.019, OR 0.646, 95% CI 0.448-0.932). However, this association lost significance after FDR correction (P.adjust = 0.456).