Another probable hereditary reason for insulin resistance in PCOS is a significant rate of SH2 domain-containing adaptor protein (Lnk) activity in PCOS female's ovarian cell lines, which suppresses the MAPK-ERK and phosphatidylinositol 3-kinase-AKT signaling responses to insulin. The gene discussed is SH2B3; the disease is polycystic ovary syndrome.