Clinically, over-regulated or dysregulated NLRP3 inflammasome activation in SARS-CoV and SARS-CoV-2-infected patients could trigger a cytokine storm that causes tissue damage and organ failure in patients with severe SARS or COVID-19 leading to death (Freeman and Swartz, 2020; van den Berg and Te Velde, 2020). Here, NLRP3 is linked to COVID-19.