The ROC curve analysis of this study showed that the AUC of serum CysC, IMA, and LP-PLA2 in patients with T2DM with LEASOD were 0.806, 0.772, and 0.781, respectively, and the AUC of patients with a combined diagnosis of the three was 0.863. The gene discussed is PLA2G7; the disease is type 2 diabetes mellitus.