However, B3GALT3 develops different effects in different tumours, research shows that B4GALT3 overexpression can promote tumour growth and invasion in cervical cancer, neuroblastoma and GBM (Chang, et al., 2013; Sun, et al., 2016; Wu, et al., 2020), opposite to the tumour suppressor effects in colorectal and bladder cancer (Chen, et al., 2014; Liu, et al., 2018). The gene discussed is B4GALT3; the disease is urinary bladder cancer.