LTBP4 and cardiovascular disorder: Colige et al. (2019) found that FBLN5 is connected to FBLN1 via LTBP4, and ADAMTST degrades LTBP4 in cardiovascular diseases, ultimately resulting in extracellular matrix degradation and disease development. In arterial dissection, Nox1 may negatively regulate FBLN5 to degrade the arterial middle layer (Hu et al., 2019).