These data were in contrast to findings in the brain, wherein circulating IGF-1 deficiency led to signs of neuronal dysfunction such as gait defects and cognitive decline as a result of impaired neurovascular coupling when assessed at 1 year of age (Toth et al., 2014; Tarantini et al., 2017c). The gene discussed is IGF1; the disease is hyperinsulinemic hypoglycemia, familial, 4.