APOE and Alzheimer disease: The two studies reporting negative effects of a longer reproductive span on AD risk instead focused on older postmenopausal women over 70 (Geerlings et al., 2001; Najar et al., 2020), excluded patients with hysterectomy or oophorectomy (Geerlings et al., 2001; Najar et al., 2020), and in some cases did not assess use of hormonal therapy (Geerlings et al., 2001), or reported effects only in APOE-4 carriers (Geerlings et al., 2001), which could account for the mixed findings.