APOE and Alzheimer disease: Additionally, perimenopausal and postmenopausal women, especially those positive for APOE-4 genotype, exhibited the highest Aβ burden (Mosconi et al., 2017b,2021), supporting the notion that APOE-4 genotype exacerbates AD-related brain changes in women (Riedel et al., 2016), with onset in perimenopause.