In the Gothenburg H70 Birth Cohort study, the association was only significant in women who had dementia onset after 75 years of age, with the strongest occurrence after 85 years of age (Najar et al., 2020), whereas no association with AD was observed before age 85 or with APOE-4 status (Najar et al., 2020). This evidence concerns the gene APOE and Alzheimer disease.