While studies linking anti-estrogen therapies to AD risk are scarce, the evidence so far indicates no clear increase in AD risk with tamoxifen and steroidal aromatase inhibitors, as one study found a decrease in AD incidence with endocrine therapy use (Branigan et al., 2020), while another found no association with dementia incidence (Ording et al., 2013). Here, CYP19A1 is linked to dementia.