While studies linking anti-estrogen therapies to AD risk are scarce, the evidence so far indicates no clear increase in AD risk with tamoxifen and steroidal aromatase inhibitors, as one study found a decrease in AD incidence with endocrine therapy use (Branigan et al., 2020), while another found no association with dementia incidence (Ording et al., 2013). Here, CYP19A1 is linked to Alzheimer disease.