The use of tetramethylpyrazine (TMP) in experimental autoimmune encephalomyelitis animal models protects the blood-spinal cord barrier by activating the signal transducer and activator of transcription 3 (STAT3)/Suppressor of Cytokine Signaling 3 (SOCS3) signaling pathway and promoting microglia polarization from M1 to M2 phenotype (Zhang et al., 2021b). The gene discussed is SOCS3; the disease is experimental autoimmune encephalomyelitis.