In a transient MCAO model, the use of minocycline promoted microglia M2 polarization significantly reduced TNF and IL-1β levels and increased TGF-β, IL-10 and chitinase-like proteins (YM1) levels, thereby reducing cerebral infarct size, promoting vascular remodeling, and improving stroke prognosis (Yang et al., 2015). The gene discussed is TNF; the disease is stroke disorder.