Han et al. (2021) found that LINC00665 could activate the Wnt/β-catenin signaling pathway by upregulating the expression of CTNNB1, ultimately stimulating the tumorigenicity of colorectal cancer. When they explored the mechanism of LINC00665 regulating CTNNB1, they found that LINC00665 could upregulate the expression level of CTNNB1 through sponging miR-214-3p or by binding to U2AF2 protein to enhance the stability of CTNNB1 mRNA (Han et al., 2021). Here, LINC00665 is linked to colorectal cancer.