The involvement of integrin αvβ6 in activation of TGFβ was recently connected to SOX4 mediated cancer immune evasion: αvβ6 blocking antibodies could inhibit SOX4 expression and sensitize mouse models for triple negative breast cancer to T cell mediated killing in response to immune checkpoint inhibitors (Bagati et al., 2021). Here, SOX4 is linked to triple-negative breast carcinoma.