POU5F1 and leukemia: Based on our MSC data, tumorigenesis driven by CDH6/YAP1/OCT4 interactions in DR MSCs may be similar to leukemia, causing blockage of cell differentiation in various stages of hematological development [ (Lee et al., 2019) [ (Chopra and Bohlander, 2019) (Li et al., 2013).