The actin-binding protein Afadin, localized at adherent junctions, mediates planar spindle orientation in Caco-2 cyst by recruiting LGN to the lateral cortex via direct interactions with the LGN-TPR domain (Carminati et al., 2016; Gao et al., 2017; Bonucci et al., 2020) (Figure 1B). The gene discussed is GPSM2; the disease is cyst.