DNM1L and neoplasm: While most studies describing the role of DRP1 in tumor progression show that mitochondrial fission occurs through increases in total DRP1 or pS616-DRP1 expression, a recent study outlines the importance of the PKA-dependent phosphorylation of DRP1 at the serine 637 residue in inhibiting tumor cell motility (Aggarwal et al., 2019).