Indeed, fission promoting proteins—including DRP1 (Zhao et al., 2013), MFF (Seo et al., 2019), FIS1 (Karimi et al., 2021; Soares et al., 2019), and MiD49 (Zhao et al., 2020)—are often found to have increased expression in cancer compared to normal adjacent tissues (Table 2). Here, FIS1 is linked to cancer.