Indeed, fission promoting proteins—including DRP1 (Zhao et al., 2013), MFF (Seo et al., 2019), FIS1 (Karimi et al., 2021; Soares et al., 2019), and MiD49 (Zhao et al., 2020)—are often found to have increased expression in cancer compared to normal adjacent tissues (Table 2). The gene discussed is MIEF2; the disease is cancer.