Inhibition of either chaperones of the heat-shock protein of 90 kDa (HSP90) family that reside in mitochondria, or mitochondrial matrix proteases Caseinolytic Mitochondrial Matrix Peptidases Proteolytic Subunit/Chaperone Subunit X (CLPP/CLPX) impaired tumor cell invasion in vitro and metastasis in vivo (Caino et al., 2013; Seo et al., 2016). This evidence concerns the gene HSP90AB1 and neoplasm.