TNF and breast cancer: In the murine 4T1 breast cancer model, administration of Tβ4 and TGF-β1 decreased the sJAM-A levels in murine blood, and a peptide derived from the sequence of the F11R/JAM-A protein, peptide 4D (P4D), blocked the TEM of breast cancer cells in the presence of TNF/IFN and Tβ4 (Bednarek et al., 2020).