High JAM-A expression induces EMT of nasopharyngeal carcinoma (NPC) cells in vitro and in vivo via the PI3K/Akt pathway, and lncRNA P73 antisense RNA 1 T (TP73-AS1) could upregulate JAM-A expression (Tian et al., 2015; Dai et al., 2021). The gene discussed is TP73; the disease is nasopharyngeal carcinoma.