As shown by our research, based on OGT-related Up-DEGs, OGT may preserve its roles in SCLC by involving mitotic and transcription regulators (cell components), participating in mRNA splicing and nucleic acid transport (biological processes), and linking with ubiquitin protein ligase binding and RNA methyltransferase activity (molecular functions), which contributes to signaling pathways, such as “Resolution of Sister Chromatid Cohesion” and “Mitotic Prometaphase.” Such results suggest that OGT may affect the development of SCLC via its classical functions, which requires further verification. Here, OGT is linked to small cell lung carcinoma.