Astragalus polysaccharide therapy could partially restore insulin-induced protein kinase B-phosphorylation of ser473 and translocation of GLUT4 in the skeletal muscles of diabetic KKAy mice, suggesting that Astragalus can possibly act as an insulin sensitizer in the type 2 diabetes treatment [77]. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.