As the direct targets of miR-326 and miR-532-5p, MAPK1 participates in lung metastasis of hepatocellular carcinoma (HCC) cells due to tumor-associated macrophage infiltration, and it has been proven positively correlated with the expression of circASAP1, which was identified by comparing the circRNA sequence between common HCC samples and those with high metastatic potential [41]. This evidence concerns the gene MAPK1 and neoplasm.