In the univariate analysis, the presence of MetS, AFP >400 ng/ml, HBV-DNA >103 IU/ml, tumor size, multiple nodules, differentiation degree, cirrhosis, MVI, satellite nodules, laparoscope, major hepatectomy, ALBI class, NLR, PLR, Clavien–Dindo class >3, and CCI were entered into the multivariate Cox model. The gene discussed is AFP; the disease is Cirrhosis.