Both bisulfite genome sequencing and luciferase reporter gene analysis confirmed that miR-484 promoter activity and expression levels were lower in CC than in normal cervical epithelial cells, which was attributed to the direct induction of miR-484 promoter CpG hypermethylation by EZH2-mediated DNA methyltransferase 1 (DNMT1) (Table 3). Further studies indicated that miR-484 exerts anti-cancer effects by inhibiting the MMP14-TNF axis and HNF1A-Wnt axis involved in CC cell adhesion, migration, invasion and EMT expression (32) (Table 3). This evidence concerns the gene DNMT1 and cancer.