PIK3CA and colorectal carcinoma: ncRNAs for example, are involved in all CRC stages of tumorigenesis and progression influencing key signaling pathways such as: WNT/-catenin, phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt), epidermal growth factor receptor (EGFR), NOTCH1, mechanistic target of rapamycin (mTOR) and TP53 (207).