PIK3CA and colorectal carcinoma: The prevalence of genetic alterations in CRC was reported in the literature as follows: KRAS mutation 44%, NRAS mutation 4%, BRAF mutation 8.5%, NTRK1 fusion 0.5%, ERBB2 amplification 2%, PIK3CA hotspot mtation 17%, ATM mutation 5%, MET amplification 1.7%, RET fusion 0.3%, ALK fusion 0.2% (44).