KIT proto-oncogene receptor tyrosine kinase and platelet-derived growth factor receptor (PDGFR) mutations play a key role in the prognosis of gastrointestinal stromal tumors (4), while ALK receptor tyrosine kinase fusion genes (174) and beta-catenin 1 (CTNNB1) mutations (175, 176) are crucial in inflammatory myofibroblastic tumors and desmoid fibromatosis, respectively. The gene discussed is CTNNB1; the disease is inflammatory myofibroblastic tumor.