The Epi proColon® test aids the early detection of CRC and showed good sensitivity and specificity when compared with the other available non-invasive tests: stool-based guaiac fecal occult blood tests (FOBT) and fecal immunochemical tests (FIT) and blood-based CEA test (139, 140). The gene discussed is CEACAM5; the disease is colorectal carcinoma.