Third, our population of patients consists purely of fully characterized IDH mutant grade 2 gliomas according to the WHO 2016 classification of tumors (oligodendroglioma, IDH mutant and 1p19q codeleted or astrocytomas, IDH mutant), thus avoiding contamination bias by IDH wild-type or other types of grade 2 gliomas. Here, IDH1 is linked to central nervous system cancer.