Third, our population of patients consists purely of fully characterized IDH mutant grade 2 gliomas according to the WHO 2016 classification of tumors (oligodendroglioma, IDH mutant and 1p19q codeleted or astrocytomas, IDH mutant), thus avoiding contamination bias by IDH wild-type or other types of grade 2 gliomas. This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).