Moreover, studies of high-avidity WT1-specific TCR-transduced CTLs in the context of HLA-A*02:01 were conducted, and they demonstrated a high degree of lysis of CD34+ cells in fresh bone marrow or blood samples from AML patients and the potential elimination of leukemia blast cells in xenograft models (38). This evidence concerns the gene WT1 and acute myeloid leukemia.