TAAs have been classified into several categories: overexpressed antigens (e.g. survivin and TERT), lineage-restricted antigens (e.g., WT1), cancer-testis antigens (e.g., NY-ESO-1, MAGE, and PRAME), neoantigens (e.g., NPM1 and CBFB-MYH11), and HA-1 (34, 50, 51). This evidence concerns the gene BIRC5 and cancer.