USP22 and neoplasm: Additionally, tumor tissues in nude mice were observed by IHC staining, and the results found that USP22 and SIRT1expression in mice injected with plasmids expressing oe-P-p38 MAPK + sh-NC and oe-P-p38 MAPK + sh-SOST were lower than that in mice expressing oe-NC + sh-NC SOST expression in mice injected with plasmids expressing oe-P-p38 MAPK + sh-NC was lower than that in mice expressing oe-NC + sh-NC and oe-P-p38 MAPK + sh-SOST(Figure 7C).