RUNX1 and acute myeloid leukemia: Germline predisposition, such as those associated with mutations in hematopoietic transcription factors RUNX1, ANKRD26, GATA2, and ETV6, can present with different types of hematopoietic malignancies, including MDS, AML, T-cell ALL, B-cell ALL, and myeloproliferative neoplasms (MPNs).