So far, we have put forward such evidence that the deletion of MnSOD is closely related to the phenotype of cancer.(O2(-)) has the potential to treat cancer, while SOD can decompose (O2(-)).This principle is currently used in the treatment of many cancers (12).The reason is that many anti-cancer drugs can produce (O2(-)).For example, the system of xanthine oxidase can enhance the DNA destruction effect of bleomycin. Here, SOD2 is linked to cancer.