Members of the KMT2 family (e.g., KMT2A, KMT2C, and KMT2D) exhibit a high mutation rate in nonsmall cell lung cancer tumors (64, 65), and these mutations were associated with higher tumor mutational burden (TMB) and PD-L1 expression, as well as higher PD-L1+/TMB-high proportions. This evidence concerns the gene CD274 and lung cancer.