reported that the mutation frequencies in axin 1 (AXIN1), tuberous sclerosis complex subunit 2 (TSC2), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), ATRX chromatin remodeler (ATRX), and lysine methyltransferase 2C (KMT2C) were relatively higher, whereas that of catenin beta 1 (CTNNB1) was significantly lower in the Chinese HBV-positive HCC cohort versus the HBV-positive HCC subgroup from The Cancer Genome Atlas (42). The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.