Baratella et al. have hypothesized that sonic hedgehog (SHH) and Wnt5a signaling might have been associated with COVID‐19 pneumomediastinum tracheal lesions as the autopsies of COVID‐19 cases showed an irregular regenerative process with cartilage tissue remodeling (unpresented in non‐COVID‐19 cases).6 The gene discussed is SHH; the disease is COVID-19.