RYR2 and heart failure: Earlier work focused on the role of disulfide oxidation (Terentyev et al., 2008; Belevych et al., 2009) and nitrosylation (Xu et al., 1998; Sun et al., 2008; Bellinger et al., 2009), both of which increase RyR open probability under conditions of oxidative stress, again notably during heart failure (Terentyev et al., 2008).