CALR and southeast Asian ovalocytosis: As reported previously (Flatt et al., 2020), SAO RBCs failed to clear calreticulin as efficiently as control donor RBCs, suggesting greater retention of ER membranes, although mitochondrial membrane proteins (VDAC1 and SLP2) and lysosomal membrane protein (LAMP2) appeared to clear normally (Figure 2C and Supplementary Table 1).