Serum IGFBP-2, IGFBP-4, and CTGF levels were higher in DM patients than in healthy controls (median (quartile): 258.9 (176.4–326.1) ng/mL vs. 167.7 (116.1–209.4) ng/mL, p < 0.0001; 450.4 (327.3–631.8) ng/mL vs. 392.2 (339.0–480.2) ng/mL, p = 0.04; and 45.71 (38.54–57.45) ng/mL vs. 35.52 (30.23–41.52) ng/mL, p = 0.001, respectively). The gene discussed is IGFBP4; the disease is dermatomyositis.