Recent studies have reported elevated levels of IGFBPs, including IGFBP2–5 and CTGF, in lung samples, including BAL cells, BAL fluids, and lung fibroblasts of patients with idiopathic IPF, suggesting that IGFBPs might play a profibrogenic role in this disorder [11, 19–23]. Here, IGFBP2 is linked to idiopathic pulmonary fibrosis.