MAPT and early-onset autosomal dominant Alzheimer disease: Building on prior work in typical older-onset amnestic Alzheimer’s disease demonstrating the deleterious effect of Alzheimer’s disease neuropathology in the PCC on functional connectivity of the DMN,11,12 we hypothesized that increased tau in the PCC would be related to reduced posterior DMN connectivity across our group of atypical Alzheimer’s disease presentations.