MAPT and early-onset autosomal dominant Alzheimer disease: Specifically, volume loss may be a consequence of several neurological processes, including a contribution from Alzheimer’s disease-related pathologies such as tau and Aβ but also from vascular and other co-existing pathologies in older adults.67,69 This, together with the observation that structural volume loss in Alzheimer’s disease is closely related to neuropathologically defined tau deposition in Alzheimer’s disease,70–72 led us to investigate how tau and GM loss interact in relation to functional connectivity changes.