MAPT and early-onset autosomal dominant Alzheimer disease: Furthermore, compared with amyloid-negative age-matched control participants (Aβ− CN), whole brain maps of cortical tau in the Aβ+ atypical Alzheimer’s disease participants as a group revealed widespread tau deposition in regions of medial and lateral temporal cortices, medial and lateral parietal cortices including the PCC and precuneus and regions of the dorsolateral prefrontal cortex (Fig. 2A).