Functional disconnection within the DMN has been consistently reported in Alzheimer’s disease,7–10,59 and hypoconnectivity within the DMN has been related to biomarkers of Aβ and tau pathology.11,12,20 However, much of our understanding of the relationships between DMN connectivity and Alzheimer’s disease biomarkers has focused on older-onset Alzheimer’s disease patients with typical amnestic symptoms, which is only one part of the spectrum of the illness. This evidence concerns the gene MAPT and Alzheimer disease.