Although the primary drivers of the earliest symptoms in atypical phenotypes of Alzheimer’s disease (e.g. PCA, lvPPA) are observed in other domain-specific networks supporting visuospatial cognition and language, respectively,41 we hypothesized that the DMN is also critically affected across the atypical Alzheimer’s disease phenotypic spectrum, given the high levels of atrophy33–36 and tau pathology17,19,37 reported in the posterior temporal and parietal regions of the DMN in atypical phenotypes of Alzheimer’s disease. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.